Articles

Descriptions of acute transfusion reactions in the teaching hospitals of Kermanshah University of Medical Sciences, Iran

Abstract

Background: Transfusion services rely on transfusion reaction reporting to provide patient care and protect the blood supply. Unnecessary discontinuation of blood is a major wastage of scarce blood, as well as man, hours and funds. The aim of the present study was to describe the main characteristics of acute transfusion reactions reported in the 4 hospital of Kermanshah University of Medical Sciences (KUMS), Kermanshah, Iran.
Material and Methods: The study was carried out at 4 teaching hospital of Kermanshah University of Medical Sciences, Kermanshah, Iran over18 months from April 2010. All adult patients on admission in the hospitals who required blood transfusion and had establish diagnosis and consented were included in the study.
Results: In the year 2010 until 2012, a total of 6238 units of blood components were transfused. A total of 59 (0.94%) cases of transfusion reaction were reported within this 3 years period The commonest were allergic reactions which presented with various skin manifestations s ch as urticarial, rashes and pruritus (49.2%), followed by increase in body temperature of > 1◦C from baseline which was reported as febrile non-hemolytic transfusion reaction (37.2%). pain at the transfusion site (6.8%) and hypotension (6.8%).
Conclusion: It is important that each transfusion of blood components to be monitor carefully. Many transfusion reactions are not recognized, because signs and symptoms mimic other clinical conditions. Any unexpected symptoms in a transfusion recipient should at least be considered as a possible transfusion reaction and be evaluated. Prompt recognition and treatment of acute transfusion reaction are crucial and would help in decreasing transfusion related morbidity and mortality, but prevention is preferable.

Serious hazards of transfusion annual report 1998-1999 (internet). Manchester (UK): SHOT Office; accessed 2003 Dec 12. Available from: http://www.shot.demon.co.uk

Serious hazards of transfusion annual report 1999-2000 (internet). Manchester (UK): SHOT Office; accessed 2003 Dec 12. Available from: http://www.shot.demon.co.uk

Blood transfusion in Hoff brand AV, Petitt JE, Moss PA, editors. Essential Hematology 4th ed. Oxford: Black well science; 2001. p. 307-18.

Hazard of transfusion in: Learoyd P, editors. An introduction to blood group serology and transfusion. 3rd ed. UK: Leeds blood center; 2003. P. 41-66.

Clinical blood transfusion in Hoffbrand AV, Lewis SM, Tuddenham EG, editors. Postgraduate Hematology. 4th ed. UK: Butterworth Heinemann; 1999.p. 215-34.

Vincent JL, Baron JF, Reinhart K, Gattinoni L, Thijs L, Webb A, Meier-Hellmann A, Nollet G, Peres-Bota D ABC (Anemia and Blood Transfusion in Critical Care) Investigators. Anemia and blood transfusion in critically ill patients. JAMA 2002; 288: 1.499-507.

Rao MP, Boralessa H, Morgan C, Soni N, Goldhill DR, Brett SJ, Boralessa H, Contreras M; North Thames Blood Interest Group. Anaesthesia 2002; 57: 527-9.

Chiavetta JÁ, Herst R, Freedman J, Axcell TJ, Wall AJ, van Rooy SC. A survey of red cell use in 45 hospitals in central Ontario, Canada. Transfusion 1996; 36: 699-706.

Henderson RA, Pinder L. N Z Med J. Acute transfusion reactions. 1990; 103(900): 509-11.

Climent-Peris C, Vélez-Rosario R. Immediate transfusion reactions. P R Health Sci J. 2001; 20(3):229-35.

Bhattacharya P, Marwaha N, Dhawan HK, Roy P, Sharma RR. Transfusion-related adverse events at the tertiary care center in North India: An institutional hemovigilance effort. Asian J Transfus Sci. 2011; 5(2):164-70.

Arewa OP, Akinola NO, Salawu L. Blood transfusion reactions; evaluation of 462 transfusions at a tertiary hospital in Nigeria. Afr J Med Med Sci. 2009; 38(2):143-8.

Gauvin F, Lacroix J, Robillard P, Lapointe H, Hume H. Acute transfusion reactions in the pediatric intensive care unit. Transfusion. 2006; 46(11):1899-908.

Lozach P, Vicariot M, Le Niger C, Pomey MP, Lejeune B, Férec C, Chaperon J, Salmi LR. Evaluation of the immediate transfusion reaction incident reporting system at the Brest University Hospital CenterTransfus Clin Biol. 2001; 8(4):343-9.

Domen RE, Hoeltge GA. Allergic transfusion reactions: an evaluation of 273 consecutive reactions. Arch Pathol Lab Med. 2003; 127(3):316-20.

Grujić J, Gulan Z, Budakov Z. Importance of haemovigilance and reports on transfusion reaction in blood component therapy. Med Pregl. 2012; 65(1-2):50-3.

Jonathan P. Wallis, Anatole Lubenko, Angus W. Wells, Catherine E. Chapman. Single hospital experience of TRALI. Transfusion 2003; 43:1053-9.

Silliman CC, Boshkov LK, Mehdizadehkashi Z, Elzi DJ, Dickey WO, Podlosky L, Clarke G, Ambruso DR. Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors. Blood 2003; 15; 101(2):454-62.

Sunita Saxena, Ira A Shulman. Resurgence of the blood utilization committee. Transfusion 2003; 43: 998-1006.

Ahmadi D. Frequency of minor blood group alloantibodies in beta-Thalassemia major blood recipients in Kermanshah (1999). Behbood 2000; 5(1): 50-55.

Lavoie J. Blood transfusion risks and alternative strategies in pediatric patients. Paediatr Anaesth. 201; 21(1):14-24.

Kleinman S, Chan P, Robillard P. Risks associated with transfusion of cellular blood components in Canada. Transfus Med Rev. 2003; 17(2):120-62.

Sarkodee-Adoo CB, Kendall JM, Sridhara R, Lee EJ, Schiffer CA. The relationship between the duration of platelet storage and the development of transfusion reactions. Transfusion. 1998; 38(3):229-35.

Kelley DL, Mangini J, Lopez-Plaza I, Triulzi DJ. The utility of < or =3-day-old whole-blood platelets in reducing the incidence of febrile nonhemolytic transfusion reactions. Transfusion. 2000; 40(4):439-42.

Menitove JE, McElligott MC, Aster RH. Febrile transfusion reaction: what blood component should be given next? Vox Sang. 1982; 42(6):318-21.

Widmann FK. Untoward effects of blood transfusion: common problems and simple safeguards. Postgrad Med. 1981; 69(2):40-4.

Dzieczkowski JS, Barrett BB, Nester D, Campbell M, Cook J, Sugrue M, Andersen JW, Anderson KC. Characterization of reactions after exclusive transfusion of white cell-reduced cellular blood components. Transfusion. 1995; 35(1):20-5.

Sokolovic M, Pastores SM. Transfusion therapy and acute lung injury. Expert Rev Respir Med. 2010; 4(3):387-93.

Perrotta PL, Snyder EL. Non-infectious complications of transfusion therapy. Blood Rev. 2001; 15(2):69-83.

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IssueVol 7, No 2 (2013) QRcode
SectionArticles
Keywords
Acute transfusion reactions Febrile non-hemolytic transfusion reaction Transfusion-related acute lung injury
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How to Cite
1.
Payandeh M, Zare ME, Kansestani AN, Pakdel SF, Jahanpour F, Yousefi H, Soleimanian F. Descriptions of acute transfusion reactions in the teaching hospitals of Kermanshah University of Medical Sciences, Iran. Int J Hematol Oncol Stem Cell Res. 1;7(2):11-16.