Articles

'T-cell/Natural killer-cell neoplasms presenting as leukemia- Case series from single tertiary care center'

Abstract

Background: Mature T/ NK-cell neoplasms are a rare group of disorders and their presentation as leukemia is even rarer. Most of the previous studies have focused on mature B-cell lineage leukemias and there is a paucity of data on mature T/NK-cell lineage leukemias. We, therefore, planned this study to analyze their spectrum, frequency, morphology and immunophenotypic features.
Methods: All cases of lymphomas presenting as leukemia over a period of two and a half years were evaluated. Detailed analysis of cases with T/NK-cell lineage was done for their clinical, hematological and immunophenotypic features.
Results: A total of 262 cases of mature lymphoid neoplasms presented as leukemia during the study period. Of whom, only 8 (3.1%) cases were of T /NK-cell lineage and the remaining (96.9%) were of B-cell lineage. Of 8 cases, 4 (50%) had T-prolymphocytic leukemia, 2 (25%) had chronic lymphoproliferative disorder- natural killer cell and 1 (12.5%) case of each T-large granular lymphocytic leukemia and hepatosplenic γ/δ T-NHL.
Conclusion: T/NK-cell leukemias are rare. Along with clinical and morphological features, pattern of immunophenotypic markers is vital for their diagnosis and subcategorization.

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IssueVol 10, No 1 (2016) QRcode
SectionArticles
Keywords
Morphology Immunophenotyping NK-lineage leukemia T-lineage leukemia
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How to Cite
1.
Naseem S, Kaur M, Sachdeva M, Ahluwalia J, Das R, Varma N, Varma S. ’T-cell/Natural killer-cell neoplasms presenting as leukemia- Case series from single tertiary care center’. Int J Hematol Oncol Stem Cell Res. 2016;10(1):13-20.