Leiomyosarcoma of Inferior Vena Cava and Right Atrium with Ascites and Jaundice: A Case Report
Leiomyosarcoma is one of the soft tissue sarcomas that could originate from different parts of body and are mostly presented as retropritoneal mass. Leiomyosarcomas of vascular origin are particularly rare tumors occurring mainly in inferior vena cava (IVC). Here, we report the case of a 35-year-old male patient who presented with ascites and jaundice. Further evaluation revealed large hepatic and cardiac masses with extension to IVC. Since it was not possible to determine the point of origin of leiomyosarcoma, the patient received chemotherapy under diagnosis of metastatic leiomyosarcoma but unfortunately passed away.
Doyle LA. Sarcoma classification: an update based on the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone. Cancer. 2014; 120(12): 1763-74.
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013; 63(1):11-30.
Mingoli A, Cavallaro A, Sapienza P, et al. International registry of inferior vena cava leiomyosarcoma: analysis of a world series on 218 patients. Anticancer Res. 1996; 16(5B):3201–5.
Hines OJ, Nelson S, Quin̆ones-Baldrich WJ, et al. Leiomyosarcoma of the inferior vena cava: prognosis and comparison with leiomyosarcoma of other anatomic sites. Cancer. 1999; 85(5):1077–83.
Kapoor R, Bansal A, Sharma SC. Leiomyosarcoma of inferior vena cava: Case series of four patients. J Cancer Res Ther. 2015; 11(3): 650.
Kieffer E, Alaoui M, Piette JC, et al. Leiomyosarcoma of the inferior vena cava: Experience in 22 cases. Ann Surg 2006; 244(2):289-95.
Matić P, Vučurević G, Babić S, et al. Intracardiac extension of the inferior vena cava leiomyosarcoma with Budd-Chiari syndrome presentation: a case report. Srp Arh Celok Lek. 2015; 143(1-2): 71-3.
Sonoda H, Minamimura K, Endo Y, et al. Complete Surgical Resection of a Leiomyosarcoma Arising from the Inferior Vena Cava. Case Rep Med. 2015; 2015:342148.
Mocellin S, Rossi CR, Brandes A, et al: Adult soft tissue sarcomas: conventional therapies and molecularly targeted approaches. Cancer Treat Rev. 2006; 32(1):9-27.
Pisters PW, O'Sullivan B, Maki RG, et al: Evidence-based recommendations for local therapy for soft tissue sarcomas. J Clin Oncol. 2007; 25(8):1003-8.