Alopecia Areata and Demyelination as Paraneoplastic Manifestation in Paediatric Hodgkin's Lymphoma
Hodgkin’s Lymphoma is one of the commonly encountered lymphomas in childhood. Most of the children present with lymphadenopathy. A rare subset of children do present with constellation of atypical symptoms as paraneoplastic syndromes. We hereby present an 11-year-old boy with classical Hodgkin’s Lymphoma associated with Alopecia areata and demyelination as paraneoplastic manifestations. Both these paraneoplastic manifestations improved after initiating chemotherapy (ABVD regimen). A high index of suspicion for underlying malignancy would help clinicians in clinching an early diagnosis and would avert the associated complications.
Hodgkin. On some Morbid Appearances of the Absorbent Glands and Spleen. Med Chir Trans. 1832; 17: 68–114.
Sherief LM, Elsafy UR, Abdelkhalek ER, et al. Hodgkin Lymphoma in Childhood: Clinicopathological features and therapy outcome at 2 Centers From a Developing Country. Medicine (Baltimore). 2015; 94(15):e670.
Rico JF, Tebbi CK. Hodgkin Lymphoma in Children : A Review. Austin J Pediatr. 2014; 1(3):1–7.
Shenoy P, Maggioncalda A, Malik N, et al. Incidence patterns and outcomes for Hodgkin lymphoma patients in the United States. Adv Hematol. 2011; 2011: 725219.
Campo E, Swerdlow SH, Harris NL, et al. The 2008 WHO classification of lymphoid neoplasms and beyond : evolving concepts and practical applications. Blood.2011; 117(19):5019–32.
Foltz LM, Song KW, Connors JM. Hodgkin’s Lymphoma in Adolescents. J Clin Oncol. 2006; 24(16):2520–6.
Madani S, Shapiro J. Alopecia areata update. J Am Acad Dermatol. 2000; 42(4):549-66.
Garg S, Mishra S, Tondon R, et al. Hodgkin’s Lymphoma Presenting as Alopecia. Int J Trichology. 2012; 4(3):169–171.
Khamaganova I, Khromova S, Shvec O. Alopecia in Lymphomas. Hair Ther Transplant. 2014; 4(1):1–4.
Scheinfeld N. Review of scalp alopecia due to a clinically unapparent or minimally apparent neoplasm (SACUMAN). Acta Derm Venereol. 2006; 86(5):387–92.
Anderson LA, Gadalla S, Morton LM, et al. Population-based study of autoimmune conditions and the risk of specific lymphoid malignancies. Int J Cancer. 2009; 125(2):398–405.
Mlczoch L, Attarbaschi A, Dworzak M, et al. Alopecia areata and multifocal bone involvement in a young adult with Hodgkin’s disease. Leuk Lymphoma. 2005; 46(4):623–7.
Ramot Y, Gural A, Zlotogorski A. Alopecia Areata as a Manifestation of Systemic Lymphoma: Report of Two Cases. Skin Appendage Disord. 2016; 2(1–2):63–6.
Graus F, Delattre JY, Antoine JC, et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry. 2004; 75 (8):1135–40.
Dalmau J, Rosenfeld MR. Paraneoplastic syndromes of the CNS. Lancet Neurol. 2008; 7(4):327–40.
Graus F, Arino H, Dalmau J. Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas. Blood. 2014; 123(21):3230–8.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.