Massive Splenomegaly: A Rare Presentation of Megaloblastic Anemia
Abstract
Megaloblastic anemia is a common disorder with various manifestations. Of the many causes, cobalamin or folate deficiency can eventuate into megaloblastic anemia. It can lead to pancytopenia and mild to moderate splenomegaly, but massive splenomegaly rarely seen in this situation. We describe a 39-year-old woman with marked enlargement of the spleen and pancytopenia that was found to have megaloblastic anemia. The splenomegaly and blood count resolved 4 months after initiation of vitamin B12 therapy. It is important to know massive splenomegaly may occur in megaloblastic anemia, and although it is rare, bur can reversible with early treatment.
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14. Behera V, Randive M, Sharma P, et al. Megaloblastic anemia presenting with massive reversible splenomegaly. Indian J Hematol Blood Transfus . 2015;31(2):297-9.
2. Wickramasinghe SN. Diagnosis of megaloblastic anaemias. Blood Rev. 2006;20(6):299-318.
3. Maktouf C, Bchir A, Louzir H, et al. Megaloblastic anemia in North Africa. Haematologica. 2006;91(7):990-1.
4. Langan RC, Zawistoski KJ. Update on vitamin B12 deficiency. Am Fam Physician . 2011 15;83(12):1425-30.
5. Stabler SP. Clinical practice. Vitamin B12 deficiency. N Engl J Med. 2013;368(2):149-60.
6. Jameson JL, Kasper DL, Longo DL, Fauci AS, Hauser SL, Loscalzo J. Harrison's principles of internal medicine, 20rd edn. New York: McGraw-Hill Education, 2018
7. Wintrobe MM, Greer JP. Wintrobe's clinical hematology, 13rd edn. Philadelphia, Pennsylvania : Lippincott Williams & Wilkins, 2014.
8. Rojas Hernandez CM, Oo TH. Advances in mechanisms, diagnosis, and treatment of pernicious anemia. Discov Med . 2015;19(104):159-68.
9. Klee GG. Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate. Clin Chem . 2000;46(8 Pt 2):1277-83.
10. Andres E, Affenberger S, Zimmer J, et al. Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin deficiency. Clin Lab Haematol . 2006;28(1):50-6.
11. Bezerra AS, D'Ippolito G, Faintuch S, et al. Determination of splenomegaly by CT: is there a place for a single measurement?. AJR Am J Roentgenol . 2005;184(5):1510-3.
12. Halfdanarson TR, Walker JA, Litzow MR, et al. Severe vitamin B12 deficiency resulting in pancytopenia, splenomegaly and leukoerythroblastosis. Eur J Haematol . 2008;80(5):448-51.
13. Belen B, Hismi BO, Kocak U. Severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis in two Syrian refugee infants: a challenge to differentiate from acute leukaemia. BMJ Case Rep . 2014;2014:bcr2014203742.
14. Behera V, Randive M, Sharma P, et al. Megaloblastic anemia presenting with massive reversible splenomegaly. Indian J Hematol Blood Transfus . 2015;31(2):297-9.
| Files | ||
| Issue | Vol 15, No 2 (2021) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/ijhoscr.v15i2.6044 | |
| Keywords | ||
| Megaloblastic anemia; Splenomegaly; Vitamin B12 | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Gholipour T, Sadeghi A, Oghab P, Farrokhi P, Moghaddas A. Massive Splenomegaly: A Rare Presentation of Megaloblastic Anemia. Int J Hematol Oncol Stem Cell Res. 2021;15(2):132-134.
