Adrenal Insufficiency in Patients with Beta-Thalassemia Major in the Southeast of Iran
-
Ghasem Miri-Aliabad
,
Maryam Nakhaie Moghadam
,
Majid Naderi
,
Mahdie Saravani
,
Ramin Saravani
,
Saman Sargazi
,
Milad Shirvaliloo
Abstract
Beta-thalassemia is a hereditary blood disorder in which the synthesis of the hemoglobin beta chain is halted or severely diminished, chiefly due to genetic mutations. As of today, the province of Sistan and Baluchistan has the highest prevalence of this disease in the southeast of Iran, with about 3,000 thalassemia patients. Adrenal dysfunction has been reported to arise in patients with beta-thalassemia major due to iron deposition in adrenal glands. We aimed to determine the prevalence of adrenal insufficiency in children with β-thalassemia major, who had been referred to Ali Asghar Hospital, Zahedan, prior to the time of the study.
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3. Gandhi PG, Shah NS, Khandelwal AG, et al. Evaluation of low dose ACTH stimulation test in suspected secondary adrenocortical insufficiency. J Postgrad Med. 2002;48(4):280-2.
4. Karimi M, Zarei T, Haghpanah S, Azarkeivan A, Kattamis C, Ladis V, et al. Evaluation of endocrine complications in beta-thalassemia intermedia (β-TI): a cross-sectional multicenter study. Endocrine. 2020;69(1):220-7.
5. Matin S , Ghanei Jahromi M , Karemizadeh Z, et al. The frequency of adrenal insufficiency in adolescents and young adults with thalassemia major versus thalassemia intermedia in Iran. Mediterr J Hematol Infect Dis. 2015;7(1):e2015005
2. Banani S and, Omrani GH. Cortisol and adrenocorticotropic hormone response to surgical stress (splenectomy) in thalassemic patients. Pediatr Surg Int. 2000; 16(5-6): 400-3.
3. Gandhi PG, Shah NS, Khandelwal AG, et al. Evaluation of low dose ACTH stimulation test in suspected secondary adrenocortical insufficiency. J Postgrad Med. 2002;48(4):280-2.
4. Karimi M, Zarei T, Haghpanah S, Azarkeivan A, Kattamis C, Ladis V, et al. Evaluation of endocrine complications in beta-thalassemia intermedia (β-TI): a cross-sectional multicenter study. Endocrine. 2020;69(1):220-7.
5. Matin S , Ghanei Jahromi M , Karemizadeh Z, et al. The frequency of adrenal insufficiency in adolescents and young adults with thalassemia major versus thalassemia intermedia in Iran. Mediterr J Hematol Infect Dis. 2015;7(1):e2015005
| Files | ||
| Issue | Vol 16, No 3 (2022) | |
| Section | Editorial | |
| DOI | https://doi.org/10.18502/ijhoscr.v16i3.10140 | |
| Keywords | ||
| Adrenal insufficiency; Beta-thalassemia; Cosyntropin; Cortisol | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Miri-Aliabad G, Nakhaie Moghadam M, Naderi M, Saravani M, Saravani R, Sargazi S, Shirvaliloo M. Adrenal Insufficiency in Patients with Beta-Thalassemia Major in the Southeast of Iran. Int J Hematol Oncol Stem Cell Res. 2022;16(3):174-176.
