Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population

Introduction: Human Leukocyte Antigen (HLA) genes are the most polymorphic loci in the human genome. They predict the outcome of transplantation by detecting self from non-self antigens. The best use of HLA typing is to find a HLA-match donor for BMT candidate patients. Evidence suggests that matching unrelated donors and recipients for HLA-A, -B and -DRB1 loci is a prediction for an improved outcome.
Methods and materials: HLA-A and -B of six hundred Iranian cord blood samples were typed by PCR-SSP method and the frequency of loci were estimated.
Results: The most frequent alleles were A*02(18.16), A*24(16.41), B*35(21.66) and B*51(13.35), respectively.
Discussion: Our HLA typing data show similarity between neighbor and related countries and Caucasians. Identifying HLA alleles helps to find suitable donors for patients in need of hematopoietic stem cell transplantation.

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Issue	Vol 3, No 2 (2009)
Section	Articles
Keywords
HLA Cord Blood GvHD Frequency Transplantation Donor

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Ghashghaie A, Alimoghaddam K, Ostadali MR, Ghaffari H- o- allah, Khansari L, Sadraee M, Mirrasekhian E, Mohyedin I, Raoofi F, Noori Z, Yaghmaian H, Eshaghi H, Ghavamzadeh A. Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population. Int J Hematol Oncol Stem Cell Res. 1;3(2):18-20.

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