Serum Zinc Values in Adult Patients Undergoing Bone Marrow Transplantation
Introduction: Zinc (Zn) deficiency can cause significant defects in cellular immunity. Hematopoietic stem cell transplantation (HSCT) patients usually experience serious deficiencies of all components of the immune system. Therefore, the maintenance of a normal Zn status may be important in this group of patients.
Patients and Methods: Serum Zn levels were analyzed in 55 patients during the HSCT period. As Zn-related factors, serum copper (Cu) levels and alkaline phosphatase (ALP) activity were also measured.
Results: There was decrease in Zn values immediate post-transplant period (at day +10) when compared to pre-HSCT levels (P=0.06). In patients who developed hypozincemia, adverse events appeared to occur more frequently.
Conclusion: This study suggests that maintaining a normal Zn status can be important in HSCT patients and Zn deficiency may be a risk factor causing adverse effects.
Antila HM, Salo MS, Kirvela O, et al. Serum Trace Element Concentration and Iron Metabolism in Allogeneic Bone Marrow Transplant Recipients. Ann Med 1992; 24:55- 59.
Herrmann VM, Petruska PJ. Marrow Transplant Recipients. Nutr Clin Pract 1993; 8:19-27.
Papadopoulou A, Nathavitharana K, Williams MD, et al. Diagnosis and Clinical Association of Zinc Depletion Following Bone Marrow Transplantation. Arch Dis Child 1996; 74:328-331.
Meerarani P, Ramadass P, Toborek M, et al. Zinc Protects Against Apoptosis of Endothelial Cells Induced by Linoleic Acid and Tumor Necrosis Factor Alpha. Am J Clin Nutr 2000; 71:81-87.
Prasad AS. Effects of Zinc Deficiency on Immune Functions. J Trace Element Exp Med 2000; 13:1-20.
Shankar AH, Parsad AS. Zinc and Immune Function: The Biological Basis of Altered Resistance to Infection. Am J Clin Nutr 1998; 68:447S-463S.
Parkman R, Weinberg K. Immunological Reconstitution Following Hematopoietic Stem Cell Transplant. In: Thomas ED, Blume KG, Forman SJ, eds. Hematopoietic Cell Transplantation, 2nd ed. Oxford, UK: Blackwell Science, 1999; 704-735.
Papadopoulou A, MacDonald A, Williams MD, et al. Enteral Nutrition after Bone Marrow Transplantation. Arch Dis Child 1997; 77:131-136.
Papadopoulou A, Williams MD, Darbyshire PJ, et al. Nutritional Support in Children Undergoing Bone Marrow Transplantation. Clin Nutr 1998; 17:57-63.
Uckkan D, Cetin M, Dincer N, et al. Serum Zinc and Alkaline Phosphatatse Values in Pediatric Bone Marrow Transplantation Patients. Pediatr Hematol Oncol 2003; 20:265-271.
Chan S, Gerson B, Subramanniam S. The Role of Cupper, Molybdenum, Selenium and Zinc in Nutrition and Health. Clin lab Med 1998; 18:673-685.
|Issue||Vol 3, No 3 (2009)|
|Zinc Copper Trace Elements Micronutrients Hematologic Neoplasms Stem Cell Transplantation|
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