Case Report

High-Burden Metastatic Prostate Cancer Mimicking Lymphoma: A Case of Extensive Lymphadenopathy

Abstract

Supradiaphragmatic lymphadenopathy is a rare finding in prostate cancer. The occurrence of multiple lymphadenopathies forming a conglomerate that resembles lymphoma is also rarely encountered in prostate cancer diagnosis. We present the case of a 71-year-old man who has experienced bilateral leg swelling in the last four months. Multiple lymphadenopathies were detected in the intra-abdominal and supradiaphragmatic regions, along with several metastatic bone lesions. Histopathological and immunohistochemical evaluations confirmed a diagnosis of prostate adenocarcinoma, not otherwise specified (NOS), with a Gleason score of 4+3=7, classified as grade group III, indicating high-volume metastatic prostate cancer. The patient was treated with docetaxel and anti-androgen therapy. His condition was improved after eight cycles of chemotherapy, and his prostate-specific antigen (PSA) levels returned to normal.

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IssueVol 20 No 1 (2026) QRcode
SectionCase Report(s)
DOI https://doi.org/10.18502/ijhoscr.v20i1.21019
Keywords
metastatic prostate cancer lymphadenopathy chemotherapy hormonal therapy case report
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Cahyanur R, Priantono D, Kurniawan A, Rahman F, Miranda M, Rahadiani N, Izza E. High-Burden Metastatic Prostate Cancer Mimicking Lymphoma: A Case of Extensive Lymphadenopathy. Int J Hematol Oncol Stem Cell Res. 2026;20(1):122-126.