Serpentine Supravenous Hyperpigmentation in an HIV Patient Receiving R-CHOP for DLBCL
Serpentine supravenous hyperpigmentation (SSH) is a rare vasculo-cutaneous entity that has been associated with peripheral infusion of chemotherapy agents, in particular 5-FU1-3,but also seen with docetaxel4,5, fotemustine6, and vinorelbine7. It consists of a marked hyperpigmentation along the superficial network of veins proximal to the chemotherapy infusion site and was originally described in a 1976 case report in association with 5-FU1. Here, for the first time, we report SSH in association with R-CHOP chemotherapy
Hrushesky WJ. Serpentine supravenous 5-fluorouracil (NSC-19893) hyperpigmentation. Cancer Treat Rep. 1976; 60(5):639.
Jain V, S. Bhandary GN. Prasad GN, et al. Serpentine supravenous streaks induced by 5-fluorouracil. J Am Acad Dermatol. 2005; 53(3):529-30.
Rao R, Balachandran C. Serpentine supravenous pigmentation. A rare vasculo-cutaneous effect induced by systemic 5-fluorouracil. Indian J Dermatol Venereol Leprol. 2010; 76(6):714-5.
Aydogan I, Kavak A, Parlak AH, et al. Persistent serpentine supravenous hyperpigmented eruption associated with docetaxel. J Eur Acad Dermatol Venereol. 2005; 19(3):345-7.
Das A, Kumar D, Mohanty S, et al. Serpentine supravenous hyperpigmentation induced by docetaxel. Indian J Dermatol Venereol Leprol. 2015; 81(4): 434.
Claudy AL, Lévigne V , et al. Serpentine supravenous hyperpigmentation induced by the nitrosourea fotemustine. Dermatology. 1992; 184(1): 70-2.
Roach EC, Petekkaya I, Gezgen G, et al. Serpentine supravenous hyperpigmentation resulting from vinorelbine administration. Breast J. 2015; 21(3): 311-2.
Marcoux D, Anex R, Russo P. Persistent serpentine supravenous hyperpigmented eruption as an adverse reaction to chemotherapy combining actinomycin and vincristine. J Am Acad Dermatol. 2000; 43(3): 540-6.
Kavak A, Karahacıoğlu FB, Gül I , et al. Persistent serpentine supravenous hyperpigmented eruption in leprosy. J Am Acad Dermatol. 2012; 67(2): e77-8.
Narang T, Dogra S, et al. Persistent serpentine supravenous hyperpigmented eruption in lepromatous leprosy after minocycline. Lepr Rev. 2015; 86(2): 191-4.
Avarbock AB, Gill KZ, Lauren CT, et al. Serpentine supravenous hyperpigmentation secondary to superficial venous thrombosis in autoimmune hemolytic anemia. Int J Dermatol. 2014; 53(2): e96-7.
O'Malley JT, Lieb JL, Weiser JA, et al. Persistent serpentine supravenous hyperpigmentation--a possible cutaneous manifestation of HIV infection or a normal
|Issue||Vol 12, No 1 (2018)|
|Serpentine supravenous hyperpigmentation SSH Chemotherapy R- CHOP DLBCL|
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